LMPD Database

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LMP001831

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 39, subfamily A, polypeptide 1
Protein EntryCP39A_HUMAN
UniProt IDQ9NYL5
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) = (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI
FunctionInvolved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityLiver specific.