LMPD Database

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LMP001808

UniProt Annotations

Entry Information
Gene Nameoxysterol binding protein
Protein EntryOSBP1_HUMAN
UniProt IDP22059
SpeciesHuman
Comments
Comment typeDescription
DomainThe PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
DomainThe second coiled-coil domain is required for interaction with the tyrosine phosphatase.
FunctionBinds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
InteractionO75344:FKBP6; NbExp=2; IntAct=EBI-2681902, EBI-744771;
Sequence CautionSequence=AAH63121.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence= ;
SimilarityBelongs to the OSBP family.
SimilarityContains 1 PH domain. {ECO
Subcellular LocationCytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes.
SubunitHomodimer or homotrimer. Interacts with VAPA.
Tissue SpecificityWidely expressed.