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LMP001752

Record overview

LMPD IDLMP001752
Gene ID10800
SpeciesHomo sapiens (Human)
Gene Namecysteinyl leukotriene receptor 1
Gene SymbolCYSLTR1
SynonymsCYSLT1; CYSLT1R; CYSLTR; HMTMF81
ChromosomeX
Map LocationXq13.2-q21.1
SummaryThis gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for CYSLTR1

Proteins

cysteinyl leukotriene receptor 1
Refseq ID:NP_001269115
Protein GI:532164733
UniProt ID:Q38Q88
mRNA ID:NM_001282186
Length:337
RefSeq Status:REVIEWED
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLST
YALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFII
PFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
 
cysteinyl leukotriene receptor 1
Refseq ID:NP_001269117
Protein GI:532164737
UniProt ID:Q38Q88
mRNA ID:NM_001282188
Length:337
RefSeq Status:REVIEWED
Protein sequence is identical to GI:532164733 (mRNA isoform)
 
cysteinyl leukotriene receptor 1
Refseq ID:NP_001269116
Protein GI:532164735
UniProt ID:Q38Q88
mRNA ID:NM_001282187
Length:337
RefSeq Status:REVIEWED
Protein sequence is identical to GI:532164733 (mRNA isoform)
 
cysteinyl leukotriene receptor 1
Refseq ID:NP_006630
Protein GI:5729798
UniProt ID:Q38Q88
mRNA ID:NM_006639
Length:337
RefSeq Status:REVIEWED
Protein sequence is identical to GI:532164733 (mRNA isoform)