LMPD Database

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LMP001750

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group I, member 3
Protein EntryQ14994_HUMAN
UniProt IDQ14994
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=15; Name=1; IsoId=Q14994-1; Sequence=Displayed; Name=2; IsoId=Q14994-2; Sequence=VSP_010634; Name=3; IsoId=Q14994-3; Sequence=VSP_043144; Name=4; IsoId=Q14994-4; Sequence=VSP_043730, VSP_043731; Name=5; IsoId=Q14994-5; Sequence=VSP_043730, VSP_010634; Name=6; IsoId=Q14994-6; Sequence=VSP_043730, VSP_010634, VSP_043732; Name=7; IsoId=Q14994-7; Sequence=VSP_043731; Name=8; IsoId=Q14994-8; Sequence=VSP_043732; Name=9; IsoId=Q14994-9; Sequence=VSP_043730, VSP_010634, VSP_046144; Name=10; IsoId=Q14994-10; Sequence=VSP_043730, VSP_010634, VSP_043732, VSP_046144; Name=11; IsoId=Q14994-11; Sequence=VSP_043730, VSP_043732, VSP_046144; Name=12; IsoId=Q14994-12; Sequence=VSP_046144; Name=13; IsoId=Q14994-13; Sequence=VSP_055180, VSP_043732, VSP_046144; Name=14; IsoId=Q14994-15; Sequence=VSP_043731, VSP_046144; Name=15; IsoId=Q14994-16; Sequence=VSP_043730, VSP_043731, VSP_046144;
DomainComposed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
FunctionBinds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
InductionBy dexamethasone.
PtmPhosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7.
SubunitInteracts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity).
Tissue SpecificityPredominantly expressed in liver.