LMPD Database

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LMP001743

UniProt Annotations

Entry Information
Gene Namemevalonate kinase
Protein EntryKIME_MOUSE
UniProt IDQ9R008
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate.
Enzyme RegulationFarnesyl- and geranyl-pyrophosphates are competitive inhibitors. {ECO:0000250}.
FunctionMay be a regulatory site in cholesterol biosynthetic pathway.
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
SimilarityBelongs to the GHMP kinase family. Mevalonate kinase subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.