LMPD Database

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LMP001735

UniProt Annotations

Entry Information
Gene NameG protein-coupled receptor 6
Protein EntryGPR6_MOUSE
UniProt IDQ6YNI2
SpeciesMouse
Comments
Comment typeDescription
CautionWas originally (PubMed:14592418) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human. {ECO:0000305|PubMed:14592418}.
Disruption PhenotypeDeficient mice show reduced striatal cyclic AMP production and selective alterations in instrumental conditioning. {ECO:0000269|PubMed:17934457}.
FunctionOrphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). {ECO:0000250}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000305|PubMed:17284443}; Multi-pass membrane protein {ECO:0000305|PubMed:17284443}. Note=Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment.
Tissue SpecificityMainly expressed in the brain. Selectively expressed in striatopallidal neurons in the striatum. {ECO:0000269|PubMed:17284443, ECO:0000269|PubMed:17934457}.