LMPD Database

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LMP001715

UniProt Annotations

Entry Information
Gene Namediacylglycerol lipase, beta
Protein EntryDGLB_MOUSE
UniProt IDQ91WC9
SpeciesMouse
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
FunctionCatalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAC39734.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305};
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityIn embryonic brains, it is present in axonal tracts, while in adults it localizes to dendritic fields, correlating with the developmental change in requirement for 2-AG synthesis from the pre- to the postsynaptic compartment (at protein level). {ECO:0000269|PubMed:14610053}.