LMPD Database

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LMP001705

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2A
Protein EntryLPP1_MOUSE
UniProt IDQ61469
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61469-1; Sequence=Displayed; Name=2; IsoId=Q61469-2; Sequence=VSP_009652;
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
FunctionBroad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P.
InductionModerately, by hydrogen peroxide, calcium ionophore and dexamethasone. {ECO:0000269|PubMed:7556647}.
MiscellaneousOverexpression elicited a number of phenotypic alteration without affecting several aspects of LPA signaling. Phenotypic abnormalities affect primarily three organs: the liver, the skin, and the reproductive organs. There is a reduction on body size, birth weight, abnormalities in fur growth, and a severely impaired spermatogenesis.
PtmN-glycosylated. Contains high-mannose oligosaccharide.
Sequence CautionSequence=AAA85353.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
SimilarityBelongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Note=Found predominantly in plasma membrane.
SubunitHomodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability. {ECO:0000269|PubMed:14725715}.
Tissue SpecificityHighly expressed in kidney and lung. Almost undetectable in brain, heart, bone, muscle or spleen.