LMPD Database

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LMP001695

UniProt Annotations

Entry Information
Gene Nameceramide synthase 5
Protein EntryCERS5_MOUSE
UniProt IDQ9D6K9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D6K9-1; Sequence=Displayed; Name=2; IsoId=Q9D6K9-2; Sequence=VSP_011192, VSP_011193;
Catalytic ActivityAcyl-CoA + sphingosine = CoA + N- acylsphingosine.
FunctionDihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1. {ECO:0000269|PubMed:12912983, ECO:0000269|PubMed:16100120}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityContains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationNucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12912983}; Multi-pass membrane protein {ECO:0000269|PubMed:12912983}.
Tissue SpecificityUbiquitously expressed, with highest levels in testis and kidney. {ECO:0000269|PubMed:12912983, ECO:0000269|PubMed:15823095}.