LMPD Database

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LMP001681

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC domain containing 17
Protein EntryZDH17_MOUSE
UniProt IDQ80TN5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q80TN5-1; Sequence=Displayed; Name=2; IsoId=Q80TN5-2; Sequence=VSP_010026, VSP_010027;
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity. {ECO:0000250}.
FunctionPalmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. {ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603741}.
InductionUp-regulated by low extracellular Mg(2+). {ECO:0000269|PubMed:18794299}.
PtmAutopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAH58772.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC30090.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC30097.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC32912.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC65688.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. {ECO:0000305}.
SimilarityContains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
SimilarityContains 5 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HD in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus. {ECO:0000269|PubMed:12393793}.
SubunitInteracts (via ANK repeats) with HD. {ECO:0000250}.
Tissue SpecificityExpressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain. {ECO:0000269|PubMed:12393793}.