LMPD Database

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LMP001672

UniProt Annotations

Entry Information
Gene Nameceramide synthase 4
Protein EntryCERS4_MOUSE
UniProt IDQ9D6J1
SpeciesMouse
Comments
Comment typeDescription
FunctionMay be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner. {ECO:0000269|PubMed:12912983}.
SimilarityContains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationNucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12912983}; Multi-pass membrane protein {ECO:0000269|PubMed:12912983}.
Tissue SpecificityUbiquitously expressed, with highest levels in skin. {ECO:0000269|PubMed:12912983, ECO:0000269|PubMed:15823095}.