LMPD Database

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LMP001608

UniProt Annotations

Entry Information
Gene Nameinositol-trisphosphate 3-kinase C
Protein EntryIP3KC_HUMAN
UniProt IDQ96DU7
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
DiseaseKawasaki disease (KWD) [MIM
Enzyme RegulationActivated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.
FunctionCan phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
SimilarityBelongs to the inositol phosphokinase (IPK) family.
Subcellular LocationNucleus . Cytoplasm . Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
Tissue SpecificityHighly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.