LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001581

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 11, subfamily B, polypeptide 2
Protein EntryC11B2_HUMAN
UniProt IDP19099
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityA steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
Catalytic ActivityCorticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O.
CofactorName=heme; Xref=ChEBI
DiseaseCorticosterone methyloxidase 1 deficiency (CMO-1 deficiency) [MIM
DiseaseCorticosterone methyloxidase 2 deficiency (CMO-2 deficiency) [MIM
DiseaseFamilial hyperaldosteronism 1 (FH1) [MIM
FunctionPreferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationMitochondrion membrane.
Web ResourceName=Wikipedia; Note=CYP11B2 entry; URL="http://en.wikipedia.org/wiki/CYP11B2";