LMPD Database

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LMP001558

Record overview

LMPD IDLMP001558
Gene ID5468
SpeciesHomo sapiens (Human)
Gene Nameperoxisome proliferator-activated receptor gamma
Gene SymbolPPARG
SynonymsCIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma
Chromosome3
Map Location3p25
SummaryThis gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PPARG

Proteins

peroxisome proliferator-activated receptor gamma isoform 1
Refseq ID:NP_005028
Protein GI:116284368
UniProt ID:P37231
mRNA ID:NM_005037
Length:477
RefSeq Status:REVIEWED
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHE
EPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSD
IDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGL
LNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
 
peroxisome proliferator-activated receptor gamma isoform 1
Refseq ID:NP_619725
Protein GI:116284373
UniProt ID:P37231
mRNA ID:NM_138711
Length:477
RefSeq Status:REVIEWED
Protein sequence is identical to GI:116284368 (mRNA isoform)
 
peroxisome proliferator-activated receptor gamma isoform 1
Refseq ID:NP_619726
Protein GI:116284370
UniProt ID:P37231
mRNA ID:NM_138712
Length:477
RefSeq Status:REVIEWED
Protein sequence is identical to GI:116284368 (mRNA isoform)
 
peroxisome proliferator-activated receptor gamma isoform 2
Refseq ID:NP_056953
Protein GI:20336229
UniProt ID:P37231
mRNA ID:NM_015869
Length:505
RefSeq Status:REVIEWED
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQ
EYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLA
VGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV
KFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEI
YKDLY