LMPD Database

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LMP001522

UniProt Annotations

Entry Information
Gene Nameadiponectin receptor 2
Protein EntryADR2_HUMAN
UniProt IDQ86V24
SpeciesHuman
Comments
Comment typeDescription
DomainThe N-terminus is known to be cytoplasmic while the C- terminus is known to be extracellular.
FunctionReceptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.
InteractionQ9UKG1:APPL1; NbExp=3; IntAct=EBI-1769445, EBI-741243;
Sequence CautionSequence=BAB15062.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the ADIPOR family.
Subcellular LocationMembrane ; Multi-pass membrane protein . Note=Localized to the cell membrane and intracellular organelles.
SubunitMay form homomultimer and heteromultimers.
Tissue SpecificityHighly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.
Web ResourceName=Wikipedia; Note=Adiponectin entry; URL="http://en.wikipedia.org/wiki/Adiponectin";