LMPD Database

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LMP001507

UniProt Annotations

Entry Information
Gene Namealkaline ceramidase 2
Protein EntryACER2_MOUSE
UniProt IDQ8VD53
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8VD53-1; Sequence=Displayed; Name=2; IsoId=Q8VD53-2; Sequence=VSP_020036; Note=No experimental confirmation available.;
Catalytic ActivityN-acylsphingosine + H(2)O = a carboxylate + sphingosine.
Enzyme RegulationSpecifically activated by lumenal, but not cytosolic Ca(2+). {ECO:0000250}.
FunctionHydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1- phosphate. {ECO:0000250}.
MiscellaneousUp-regulated in hepatocellular carcinomas.
Sequence CautionSequence=BAC39416.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};
SimilarityBelongs to the alkaline ceramidase family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.