LMPD Database

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LMP001503

UniProt Annotations

Entry Information
Gene Namedihydrolipoamide dehydrogenase
Protein EntryDLDH_MOUSE
UniProt IDO08749
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityProtein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
FunctionLipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
MiscellaneousThe active site is a redox-active disulfide bond.
PtmAcetylation of Lys-127 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753, ECO:0000269|PubMed:23806337}.
PtmTyrosine phosphorylated. {ECO:0000250}.
SimilarityBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomodimer. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by non-covalent bonds (By similarity). {ECO:0000250}.