LMPD Database

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LMP001494

UniProt Annotations

Entry Information
Gene Namevesicle-associated membrane protein 2
Protein EntryVAMP2_MOUSE
UniProt IDP63044
SpeciesMouse
Comments
Comment typeDescription
FunctionInvolved in the targeting and/or fusion of transport vesicles to their target membrane. {ECO:0000269|PubMed:9430681}.
InteractionP60766:Cdc42; NbExp=2; IntAct=EBI-521920, EBI-81763; P60879:Snap25; NbExp=5; IntAct=EBI-521920, EBI-445270;
SimilarityBelongs to the synaptobrevin family. {ECO:0000305}.
SimilarityContains 1 v-SNARE coiled-coil homology domain. {ECO:0000255|PROSITE-ProRule:PRU00290}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note=Neuronal synaptic vesicles.
SubunitPart of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with VAPA and VAPB (By similarity). Interacts with BVES and STX4. {ECO:0000250, ECO:0000269|PubMed:17548353, ECO:0000269|PubMed:20057356}.