LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001489

UniProt Annotations

Entry Information
Gene Namesedoheptulokinase
Protein EntrySHPK_HUMAN
UniProt IDQ9UHJ6
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.06 mM for sedoheptulose ; pH dependence: Optimum pH is 8.5. ;
Catalytic ActivityATP + sedoheptulose = ADP + sedoheptulose 7- phosphate.
FunctionActs as a modulator of macrophage activation through control of glucose metabolism.
InductionDown-regulated by LPS.
SimilarityBelongs to the FGGY kinase family.
Subcellular LocationCytoplasm .
Tissue SpecificityStrongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.