LMPD Database

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LMP001485

UniProt Annotations

Entry Information
Gene NameRab geranylgeranyltransferase, alpha subunit
Protein EntryPGTA_HUMAN
UniProt IDQ92696
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Enzyme RegulationThe enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.
FunctionCatalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
SimilarityBelongs to the protein prenyltransferase subunit alpha family.
SimilarityContains 5 LRR (leucine-rich) repeats.
SimilarityContains 6 PFTA repeats. {ECO
SubunitHeterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM