LMPD Database

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LMP001484

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-V
Protein EntryAPOA5_MOUSE
UniProt IDQ8C7G5
SpeciesMouse
Comments
Comment typeDescription
FunctionMinor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). {ECO:0000250}.
InductionInduced in early phase of liver regeneration.
MiscellaneousMice expressing the human APOAV transgene show a decrease in plasma TG by one third. Conversely, knockout mice lacking APOAV have a four time increase in plasma TG.
PtmPhosphorylation sites are present in the extracellular medium. {ECO:0000250}.
SimilarityBelongs to the apolipoprotein A1/A4/E family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000269|PubMed:11577099}.
SubunitInteracts with GPIHBP1. {ECO:0000250}.
Tissue SpecificityLiver. {ECO:0000269|PubMed:11577099, ECO:0000269|PubMed:11588264}.