LMPD Database

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LMP001460

UniProt Annotations

Entry Information
Gene Nameglycerol-3-phosphate acyltransferase, mitochondrial
Protein EntryGPAT1_MOUSE
UniProt IDQ61586
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
FunctionEsterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. {ECO:0000250}.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
SimilarityBelongs to the GPAT/DAPAT family. {ECO:0000305}.
Subcellular LocationMitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityHighest levels in liver, intermediate levels in muscle and kidney, and lowest levels in lung and brain.