LMPD Database

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LMP001447

Gene Information

Entrez Gene ID8301
Gene Namephosphatidylinositol binding clathrin assembly protein
Gene SymbolPICALM
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030118 IEA:InterProCclathrin coat
GO:0005905 IDA:UniProtKBCcoated pit
GO:0031410 IEA:UniProtKB-KWCcytoplasmic vesicle
GO:0005794 IEA:UniProtKB-KWCGolgi apparatus
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0016020 IDA:UniProtKBCmembrane
GO:0097418 IMP:Alzheimers_University_of_TorontoCneurofibrillary tangle
GO:0043025 IDA:Alzheimers_University_of_TorontoCneuronal cell body
GO:0005634 IDA:BHF-UCLCnucleus
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0045211 ISS:BHF-UCLCpostsynaptic membrane
GO:0042734 ISS:BHF-UCLCpresynaptic membrane
GO:0031982 ISS:Alzheimers_University_of_TorontoCvesicle
GO:0005545 ISS:UniProtKBF1-phosphatidylinositol binding
GO:0035615 IMP:Alzheimers_University_of_TorontoFclathrin adaptor activity
GO:0030276 IDA:UniProtKBFclathrin binding
GO:0032050 IDA:BHF-UCLFclathrin heavy chain binding
GO:0007409 IEA:EnsemblPaxonogenesis
GO:0035459 IMP:Alzheimers_University_of_TorontoPcargo loading into vesicle
GO:0008283 IMP:Alzheimers_University_of_TorontoPcell proliferation
GO:0048268 IMP:BHF-UCLPclathrin coat assembly
GO:0072583 IMP:Alzheimers_University_of_TorontoPclathrin-mediated endocytosis
GO:0048813 IEA:EnsemblPdendrite morphogenesis
GO:0016197 IMP:BHF-UCLPendosomal transport
GO:0030097 IEA:EnsemblPhemopoiesis
GO:0055072 IMP:Alzheimers_University_of_TorontoPiron ion homeostasis
GO:0097459 IMP:Alzheimers_University_of_TorontoPiron ion import into cell
GO:0010629 IMP:Alzheimers_University_of_TorontoPnegative regulation of gene expression
GO:1902963 ISS:Alzheimers_University_of_TorontoPnegative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:0048261 IDA:BHF-UCLPnegative regulation of receptor-mediated endocytosis
GO:1902961 ISS:Alzheimers_University_of_TorontoPpositive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902004 IMP:Alzheimers_University_of_TorontoPpositive regulation of beta-amyloid formation
GO:1901216 IMP:Alzheimers_University_of_TorontoPpositive regulation of neuron death
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0006461 TAS:ProtIncPprotein complex assembly
GO:0031623 IMP:BHF-UCLPreceptor internalization
GO:0006898 IDA:UniProtKBPreceptor-mediated endocytosis
GO:1902959 IMP:Alzheimers_University_of_TorontoPregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:0030100 IMP:BHF-UCLPregulation of endocytosis
GO:0032880 IDA:BHF-UCLPregulation of protein localization
GO:0016188 ISS:Alzheimers_University_of_TorontoPsynaptic vesicle maturation
GO:0016192 TAS:ProtIncPvesicle-mediated transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_19187Clathrin derived vesicle budding
REACT_19400Golgi Associated Vesicle Biogenesis
REACT_11123Membrane Trafficking
REACT_11235trans-Golgi Network Vesicle Budding