LMPD Database

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LMP001437

UniProt Annotations

Entry Information
Gene Nameadiponectin receptor 1
Protein EntryADR1_HUMAN
UniProt IDQ96A54
SpeciesHuman
Comments
Comment typeDescription
DomainThe N-terminus is known to be cytoplasmic while the C- terminus is known to be extracellular.
FunctionReceptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
InteractionSelf; NbExp=3; IntAct=EBI-1632076, EBI-1632076; Q9UKG1:APPL1; NbExp=6; IntAct=EBI-1632076, EBI-741243;
Sequence CautionSequence=AAD34040.1; Type=Frameshift; Positions=369; Evidence= ;
SimilarityBelongs to the ADIPOR family.
Subcellular LocationMembrane ; Multi-pass membrane protein . Note=Localized to the cell membrane and intracellular organelles.
SubunitMay form homomultimer and heteromultimers.
Tissue SpecificityWidely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ADIPOR1ID44512ch1q32.html";