LMPD Database

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LMP001426

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase family 1, subfamily A1
Protein EntryAL1A1_MOUSE
UniProt IDP24549
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityRetinal + NAD(+) + H(2)O = retinoate + NADH.
FunctionIn addition to the activity on acetaldehyde and related substrates, is also involved in the oxidation of aldehydes derived from biogenic amines such as epinephrine and norepinephrine, as well as the aldehydes generated via lipid peroxidation. Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity). {ECO:0000250}.
PathwayCofactor metabolism; retinol metabolism.
Sequence CautionSequence=AAH44729.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.
Tissue SpecificityExpressed in the liver, lung, and testis. Apparently not expressed at detectable levels in kidney, stomach, ovary, heart, and brain.