LMPD Database

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LMP001420

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-IV
Protein EntryAPOA4_MOUSE
UniProt IDP06728
SpeciesMouse
Comments
Comment typeDescription
DomainNine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11- mers) occurring in this sequence are predicted to be highly alpha- helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
FunctionMay have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
PolymorphismThere is a polymorphism within a series of imperfect repeats encoding the sequence E-Q-[AV]-Q. Insertions or deletions of 12 nucleotides have given rise to three forms characterized by three (129), four (C57BL/6), or five (M.castaneus) copies of the repeat unit.
SimilarityBelongs to the apolipoprotein A1/A4/E family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer. {ECO:0000250|UniProtKB:P06727}.
Tissue SpecificitySecreted in plasma.