LMPD Database

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LMP001417

UniProt Annotations

Entry Information
Gene Nameserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Protein EntryCBG_HUMAN
UniProt IDP08185
SpeciesHuman
Comments
Comment typeDescription
DiseaseCorticosteroid-binding globulin deficiency (CBG deficiency) [MIM
DomainProteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.
FunctionMajor transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
PtmGlycosylation in position Asn-260 is needed for steroid binding.
PtmN-glycosylated; binds 5 oligosaccharide chains.
SimilarityBelongs to the serpin family.
Subcellular LocationSecreted.
Tissue SpecificityPlasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
Web ResourceName=Wikipedia; Note=Transcortin entry; URL="http://en.wikipedia.org/wiki/Transcortin";