LMPD Database

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LMP001412

UniProt Annotations

Entry Information
Gene Nameglycosylphosphatidylinositol specific phospholipase D1
Protein EntryPHLD_HUMAN
UniProt IDP80108
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P80108-1; Sequence=Displayed; Name=2; IsoId=P80108-2; Sequence=VSP_023261, VSP_023262;
Catalytic Activity6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D- myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.
FunctionThis protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
Sequence CautionSequence=AAA36444.1; Type=Miscellaneous discrepancy; Note=This sequence has numerous of conflicts with the human genome.; Evidence= ;
SimilarityBelongs to the GPLD1 family.
SimilarityContains 7 FG-GAP repeats.
Subcellular LocationSecreted.
SubunitMonomer.