LMPD Database

LMP001411

Gene Information

Entrez Gene ID	5578
Gene Name	protein kinase C, alpha
Gene Symbol	PRKCA
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0045177	IEA:Ensembl	C	apical part of cell
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	IDA:UniProtKB	C	cytosol
GO:0030425	IEA:Ensembl	C	dendrite
GO:0005783	IDA:BHF-UCL	C	endoplasmic reticulum
GO:0070062	IDA:UniProt	C	extracellular vesicular exosome
GO:0005739	IDA:UniProt	C	mitochondrion
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0048471	ISS:UniProtKB	C	perinuclear region of cytoplasm
GO:0001750	IEA:Ensembl	C	photoreceptor outer segment
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0004698	IEA:Ensembl	F	calcium-dependent protein kinase C activity
GO:0019899	IDA:BHF-UCL	F	enzyme binding
GO:0035403	IDA:UniProtKB	F	histone kinase activity (H3-T6 specific)
GO:0004672	IDA:UniProtKB	F	protein kinase activity
GO:0004697	ISS:BHF-UCL	F	protein kinase C activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0007190	ISS:BHF-UCL	P	activation of adenylate cyclase activity
GO:0007202	TAS:Reactome	P	activation of phospholipase C activity
GO:0001525	IEA:UniProtKB-KW	P	angiogenesis
GO:0097190	TAS:ProtInc	P	apoptotic signaling pathway
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0007155	IEA:UniProtKB-KW	P	cell adhesion
GO:0006874	IEA:Ensembl	P	cellular calcium ion homeostasis
GO:0071322	IEA:Ensembl	P	cellular response to carbohydrate stimulus
GO:0002062	IEA:Ensembl	P	chondrocyte differentiation
GO:0002159	IMP:BHF-UCL	P	desmosome assembly
GO:0006112	TAS:Reactome	P	energy reserve metabolic process
GO:0007173	TAS:Reactome	P	epidermal growth factor receptor signaling pathway
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0008543	TAS:Reactome	P	fibroblast growth factor receptor signaling pathway
GO:0010467	TAS:Reactome	P	gene expression
GO:0035408	IDA:UniProtKB	P	histone H3-T6 phosphorylation
GO:0000188	IEA:Ensembl	P	inactivation of MAPK activity
GO:0050930	IEA:Ensembl	P	induction of positive chemotaxis
GO:0045087	TAS:Reactome	P	innate immune response
GO:0097193	IEA:Ensembl	P	intrinsic apoptotic signaling pathway
GO:0016071	TAS:Reactome	P	mRNA metabolic process
GO:0007194	ISS:BHF-UCL	P	negative regulation of adenylate cyclase activity
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0034351	IMP:UniProtKB	P	negative regulation of glial cell apoptotic process
GO:0046325	IEA:Ensembl	P	negative regulation of glucose import
GO:0046627	IEA:Ensembl	P	negative regulation of insulin receptor signaling pathway
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0030593	IEA:Ensembl	P	neutrophil chemotaxis
GO:0036289	IEA:Ensembl	P	peptidyl-serine autophosphorylation
GO:0007603	TAS:Reactome	P	phototransduction, visible light
GO:0030168	TAS:Reactome	P	platelet activation
GO:0045766	IMP:UniProtKB	P	positive regulation of angiogenesis
GO:0043536	IDA:DFLAT	P	positive regulation of blood vessel endothelial cell migration
GO:0010613	ISS:UniProtKB	P	positive regulation of cardiac muscle hypertrophy
GO:0045785	IMP:UniProtKB	P	positive regulation of cell adhesion
GO:0030335	IMP:UniProtKB	P	positive regulation of cell migration
GO:2000707	ISS:UniProtKB	P	positive regulation of dense core granule biogenesis
GO:0010595	IMP:UniProtKB	P	positive regulation of endothelial cell migration
GO:0001938	IMP:UniProtKB	P	positive regulation of endothelial cell proliferation
GO:0070374	ISS:UniProtKB	P	positive regulation of ERK1 and ERK2 cascade
GO:0050729	IEA:Ensembl	P	positive regulation of inflammatory response
GO:0031666	IMP:UniProtKB	P	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045651	ISS:UniProtKB	P	positive regulation of macrophage differentiation
GO:0045931	IMP:UniProtKB	P	positive regulation of mitotic cell cycle
GO:0001934	IEA:Ensembl	P	positive regulation of protein phosphorylation
GO:0006468	IDA:UniProtKB	P	protein phosphorylation
GO:0050796	TAS:Reactome	P	regulation of insulin secretion
GO:0006937	IEA:Ensembl	P	regulation of muscle contraction
GO:0050730	IEA:Ensembl	P	regulation of peptidyl-tyrosine phosphorylation
GO:0090330	IDA:UniProtKB	P	regulation of platelet aggregation
GO:0022400	TAS:Reactome	P	regulation of rhodopsin mediated signaling pathway
GO:0002026	IEA:Ensembl	P	regulation of the force of heart contraction
GO:0070555	IMP:BHF-UCL	P	response to interleukin-1
GO:0016056	TAS:Reactome	P	rhodopsin mediated signaling pathway
GO:0016070	TAS:Reactome	P	RNA metabolic process
GO:0007165	TAS:Reactome	P	signal transduction
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0007268	TAS:Reactome	P	synaptic transmission

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04921	Oxytocin signaling pathway
hsa04919	Thyroid hormone signaling pathway