LMPD Database

LMP001410

Gene Information

Entrez Gene ID	18145
Gene Name	Niemann-Pick type C1
Gene Symbol	Npc1
Species	Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	ISS:UniProtKB	C	endoplasmic reticulum
GO:0005768	IDA:MGI	C	endosome
GO:0005576	IDA:UniProtKB	C	extracellular region
GO:0070062	IEA:Ensembl	C	extracellular vesicular exosome
GO:0005794	IDA:MGI	C	Golgi apparatus
GO:0005887	ISS:UniProtKB	C	integral component of plasma membrane
GO:0005765	IEA:Ensembl	C	lysosomal membrane
GO:0005764	IDA:UniProtKB	C	lysosome
GO:0016020	IDA:MGI	C	membrane
GO:0045121	IDA:MGI	C	membrane raft
GO:0005635	ISS:UniProtKB	C	nuclear envelope
GO:0048471	ISS:UniProtKB	C	perinuclear region of cytoplasm
GO:0005886	IDA:MGI	C	plasma membrane
GO:0031982	IDA:MGI	C	vesicle
GO:0015485	ISS:UniProtKB	F	cholesterol binding
GO:0008158	IEA:InterPro	F	hedgehog receptor activity
GO:0007628	IGI:MGI	P	adult walking behavior
GO:0006914	ISO:MGI	P	autophagy
GO:0008206	ISS:UniProtKB	P	bile acid metabolic process
GO:0071404	IDA:MGI	P	cellular response to low-density lipoprotein particle stimulus
GO:0071383	IDA:MGI	P	cellular response to steroid hormone stimulus
GO:0033344	IMP:MGI	P	cholesterol efflux
GO:0042632	ISS:UniProtKB	P	cholesterol homeostasis
GO:0008203	IEA:UniProtKB-KW	P	cholesterol metabolic process
GO:0030301	ISS:UniProtKB	P	cholesterol transport
GO:0006897	IMP:MGI	P	endocytosis
GO:0090150	IEA:Ensembl	P	establishment of protein localization to membrane
GO:0007041	ISS:UniProtKB	P	lysosomal transport
GO:0031579	IEA:Ensembl	P	membrane raft organization
GO:0060548	IEA:Ensembl	P	negative regulation of cell death
GO:0016242	IMP:MGI	P	negative regulation of macroautophagy
GO:0006486	IDA:UniProtKB	P	protein glycosylation
GO:0046686	IEA:Ensembl	P	response to cadmium ion
GO:0042493	IDA:MGI	P	response to drug

KEGG Pathway Links

KEGG Pathway ID	Description
ko04142	Lysosome
mmu04142	Lysosome