LMPD Database

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LMP001393

UniProt Annotations

Entry Information
Gene Nameperoxiredoxin 6
Protein EntryPRDX6_MOUSE
UniProt IDO08709
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Catalytic Activity2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
FunctionInvolved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury (By similarity). {ECO:0000250}.
InteractionP19157:Gstp1; NbExp=2; IntAct=EBI-444895, EBI-2309446; O70145:Ncf2; NbExp=3; IntAct=EBI-444895, EBI-9550667;
MiscellaneousIrreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. {ECO:0000250}.
MiscellaneousThe active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6 conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly reduced to cysteine by glutathione and not thioredoxin (By similarity). {ECO:0000250}.
SimilarityBelongs to the AhpC/TSA family. Rehydrin subfamily. {ECO:0000305}.
SimilarityContains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationCytoplasm {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Also found in lung secretory organelles. {ECO:0000250}.
SubunitHomodimer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. Interacts with APEX1 and STH (By similarity). May interact with FAM168B (By similarity). May interact with HTR2A. {ECO:0000250, ECO:0000269|PubMed:14988405}.
Tissue SpecificityHighly expressed in heart, kidney and liver. Moderate expression in brain and stomach. Very low levels in intestine.