LMPD Database

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LMP001352

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Protein EntryPI42A_MOUSE
UniProt IDO70172
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
FunctionCatalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity). May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000250, ECO:0000269|PubMed:16434494}.
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular LocationNucleus {ECO:0000250}. Cytoplasm. Cell membrane. Note=Localization to the nucleus is modulated by the interaction with PIP4K2B (By similarity). Localized to the demarcation membrane system (DMS). May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light. {ECO:0000250}.
SubunitHomodimer. Interacts with PIP4K2B. Interaction with PIP4K2B may modulate localization to the nucleus (By similarity). {ECO:0000250}.
Tissue SpecificityDetected in rod photoreceptor cells. {ECO:0000269|PubMed:20204506}.