LMPD Database

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LMP001327

UniProt Annotations

Entry Information
Gene Nameinositol 1,4,5-trisphosphate receptor 1
Protein EntryITPR1_MOUSE
UniProt IDP11881
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternatively spliced domains at site SI and site SII (A, B and C). Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=SISIIABC; IsoId=P11881-1; Sequence=Displayed; Name=2; Synonyms=SI-SIIABC; IsoId=P11881-2; Sequence=VSP_002691; Name=3; Synonyms=SISIIAC; IsoId=P11881-3; Sequence=VSP_002693; Name=4; Synonyms=SI-SIIAC; IsoId=P11881-4; Sequence=VSP_002691, VSP_002693; Name=5; Synonyms=SISIIA; IsoId=P11881-5; Sequence=VSP_002693, VSP_002694; Name=6; Synonyms=SI-SIIA; IsoId=P11881-6; Sequence=VSP_002691, VSP_002693, VSP_002694; Name=7; Synonyms=SISII; IsoId=P11881-7; Sequence=VSP_002692, VSP_002693, VSP_002694; Name=8; Synonyms=SI-SII; IsoId=P11881-8; Sequence=VSP_002691, VSP_002692, VSP_002693, VSP_002694;
DomainThe receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
FunctionIntracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. {ECO:0000269|PubMed:19752026, ECO:0000269|PubMed:20813840, ECO:0000269|PubMed:2554142}.
InteractionQ9D1Q6:Erp44; NbExp=5; IntAct=EBI-541478, EBI-541567;
MiscellaneousCalcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor.
PtmPhosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels. {ECO:0000269|PubMed:18630941}.
PtmPhosphorylated on tyrosine residues. {ECO:0000250}.
PtmUbiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAA88319.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH03271.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the InsP3 receptor family. {ECO:0000305}.
SimilarityContains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:2554142}; Multi-pass membrane protein {ECO:0000269|PubMed:2554142}.
SubunitHomotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with AHCYL1 and MRVI1. Interacts with CABP1 (By similarity). Interacts with TESPA1. {ECO:0000250, ECO:0000269|PubMed:12442173, ECO:0000269|PubMed:12525476, ECO:0000269|PubMed:15652484, ECO:0000269|PubMed:16527252, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:23650607}.