LMPD Database

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LMP001319

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily C, polypeptide 19
Protein EntryCP2CJ_HUMAN
UniProt IDP33261
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(+)-(R)-limonene + NADPH + O(2) = (+)-trans- carveol + NADP(+) + H(2)O.
Catalytic Activity(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.
Catalytic Activity(-)-(S)-limonene + NADPH + O(2) = (-)-trans- carveol + NADP(+) + H(2)O.
CautionP450-254C was originally listed as a separate gene (CYP2C17). Resequencing demonstrated that it is not a separate gene, but a chimera. The 5'-portion corresponds to a partial 2C18 clone, and the 3'-portion corresponds to a partial 2C19 clone.
CofactorName=heme; Xref=ChEBI
FunctionResponsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
InductionP450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
PolymorphismGenetic variation in CYP2C19 is responsible for poor drug metabolism [MIM
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2C19 alleles; URL="http://www.cypalleles.ki.se/cyp2c19.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2c19/";