LMPD Database

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LMP001298

UniProt Annotations

Entry Information
Gene Nameneutral sphingomyelinase (N-SMase) activation associated factor
Protein EntryFAN_HUMAN
UniProt IDQ92636
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92636-1; Sequence=Displayed; Name=2; IsoId=Q92636-2; Sequence=VSP_042036; Note=No experimental confirmation available.;
FunctionCouples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
InteractionP60709:ACTB; NbExp=2; IntAct=EBI-2947053, EBI-353944; O95166:GABARAP; NbExp=2; IntAct=EBI-2947053, EBI-712001; Q9H0R8:GABARAPL1; NbExp=6; IntAct=EBI-2947053, EBI-746969; P50552:VASP; NbExp=2; IntAct=EBI-2947053, EBI-748201;
SimilarityContains 1 BEACH domain. {ECO
SimilarityContains 1 GRAM domain.
SimilarityContains 6 WD repeats. {ECO
Tissue SpecificityUbiquitous.