LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001290

UniProt Annotations

Entry Information
Gene Namegamma-glutamyltransferase 5
Protein EntryGGT5_MOUSE
UniProt IDQ9Z2A9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2A9-1; Sequence=Displayed; Name=2; IsoId=Q9Z2A9-2; Sequence=VSP_008147, VSP_008148; Note=Very low expression.;
Catalytic ActivityA (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Catalytic ActivityGlutathione + H(2)O = L-cysteinylglycine + L- glutamate.
Catalytic ActivityLeukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate.
FunctionCleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
PathwayLipid metabolism; leukotriene D4 biosynthesis.
PathwaySulfur metabolism; glutathione metabolism.
PtmCleaved by autocatalysis into a large and a small subunit. {ECO:0000250}.
SimilarityBelongs to the gamma-glutamyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitHeterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). {ECO:0000250}.
Tissue SpecificityVery low level of expression. Detected in spleen lymphocytes, medullary and paracortical thymic lymphocytes, lung interstitial cells, bronchial epithelium, proximal tubules in kidney, crypt cells in small intestine, neurons in brain stem and cerebral cortex and in Purkinje cells.