LMPD Database

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LMP001279

UniProt Annotations

Entry Information
Gene Namephosphate cytidylyltransferase 1, choline, alpha isoform
Protein EntryPCY1A_MOUSE
UniProt IDP49586
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCTP + phosphocholine = diphosphate + CDP- choline.
Enzyme RegulationBy phosphorylation. {ECO:0000250}.
FunctionControls phosphatidylcholine synthesis.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
PtmMonoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
PtmThe serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity). {ECO:0000250}.
SimilarityBelongs to the cytidylyltransferase family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. {ECO:0000250}.
SubunitHomodimer.