LMPD Database

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LMP001273

UniProt Annotations

Entry Information
Gene Namealkaline ceramidase 1
Protein EntryACER1_MOUSE
UniProt IDQ8R4X1
SpeciesMouse
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 8.0. {ECO:0000269|PubMed:12783875};
Catalytic ActivityN-acylsphingosine + H(2)O = a carboxylate + sphingosine.
Enzyme RegulationInhibited by sphingosine. Inhibited by Mn(2+), Zn(2+), and Cu(2+) in a dose-dependent manner. Slightly activated by Ca(2+) in a dose-dependent manner. {ECO:0000269|PubMed:12783875}.
FunctionHydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. {ECO:0000269|PubMed:12783875}.
SimilarityBelongs to the alkaline ceramidase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12783875}; Multi-pass membrane protein {ECO:0000269|PubMed:12783875}.
Tissue SpecificityHighly expressed in skin. Weakly or not expressed in other tissues. {ECO:0000269|PubMed:12783875}.