LMPD Database

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LMP001252

UniProt Annotations

Entry Information
Gene Nameinositol 1,4,5-trisphosphate 3-kinase C
Protein EntryIP3KC_MOUSE
UniProt IDQ7TS72
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme RegulationActivated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4 (By similarity). {ECO:0000250}.
FunctionCan phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000250}.
InteractionO54824:Il16; NbExp=3; IntAct=EBI-648015, EBI-641708;
SimilarityBelongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. {ECO:0000250}.