LMPD Database

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LMP001236

UniProt Annotations

Entry Information
Gene Nameprotein kinase D3
Protein EntryKPCD3_HUMAN
UniProt IDO94806
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O94806-1; Sequence=Displayed; Name=2; IsoId=O94806-2; Sequence=VSP_029405, VSP_029406;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mg(2+); Xref=ChEBI
Enzyme RegulationActivated by DAG and phorbol esters. Phorbol- ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain.
FunctionConverts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).
InteractionP63027:VAMP2; NbExp=7; IntAct=EBI-1255366, EBI-520113;
SimilarityBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 protein kinase domain.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers.
Subcellular LocationCytoplasm . Membrane . Note=Translocation to the cell membrane is required for kinase activation.
Tissue SpecificityUbiquitous.