LMPD Database

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LMP001230

UniProt Annotations

Entry Information
Gene Namelysophosphatidylglycerol acyltransferase 1
Protein EntryLGAT1_HUMAN
UniProt IDQ92604
SpeciesHuman
Comments
Comment typeDescription
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
FunctionLysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.
Sequence CautionSequence=BAA13196.2; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityHighly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon.