LMPD Database

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LMP001228

UniProt Annotations

Entry Information
Gene Namegroup-specific component (vitamin D binding protein)
Protein EntryVTDB_HUMAN
UniProt IDP02774
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P02774-1; Sequence=Displayed; Name=2; IsoId=P02774-2; Sequence=VSP_038427; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P02774-3; Sequence=VSP_044523; Note=No experimental confirmation available.;
FunctionMultifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
PolymorphismOver 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele.
Sequence CautionSequence=BAG60654.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence= ;
SimilarityBelongs to the ALB/AFP/VDB family.
SimilarityContains 3 albumin domains. {ECO
Subcellular LocationSecreted.