LMPD Database

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LMP001222

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Protein EntryPAFA_HUMAN
UniProt IDQ13093
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
DiseaseAsthma (ASTHMA) [MIM
DiseaseAtopic hypersensitivity (ATOPY) [MIM
DiseasePlatelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM
FunctionModulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
Subcellular LocationSecreted, extracellular space.
Tissue SpecificityPlasma.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pla2g7/";