LMPD Database

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LMP001209

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family A (ABC1), member 1
Protein EntryABCA1_MOUSE
UniProt IDP41233
SpeciesMouse
Comments
Comment typeDescription
DomainMultifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
FunctioncAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport (By similarity). {ECO:0000250}.
InductionDown-regulated by endotoxins (LPS) or cytokines (TNF and IL-1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR). {ECO:0000269|PubMed:12032171}.
PtmPalmitoylation by DHHC8 is essential for membrane localization. {ECO:0000250}.
PtmPhosphorylation on Ser-2054 regulates phospholipid efflux. {ECO:0000250}.
Sequence CautionSequence=AAG39073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53530.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ABC transporter superfamily. ABCA family. {ECO:0000305}.
SimilarityContains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitInteracts with MEGF10. {ECO:0000269|PubMed:17205124}.
Tissue SpecificityWidely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.