LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001193

UniProt Annotations

Entry Information
Gene NameN(alpha)-acetyltransferase 10, NatA catalytic subunit
Protein EntryNAA10_HUMAN
UniProt IDP41227
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P41227-1; Sequence=Displayed; Name=2; IsoId=P41227-2; Sequence=VSP_046205, VSP_046206;
Catalytic ActivityAcetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
DiseaseMicrophthalmia, syndromic, 1 (MCOPS1) [MIM
DiseaseN-terminal acetyltransferase deficiency (NATD) [MIM
FunctionCatalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. {ECO
InteractionQ15052:ARHGEF6; NbExp=3; IntAct=EBI-747693, EBI-1642523; Q14155:ARHGEF7; NbExp=3; IntAct=EBI-747693, EBI-717515; O55043:Arhgef7 (xeno); NbExp=3; IntAct=EBI-747693, EBI-3649585; Q9GZZ1:NAA50; NbExp=2; IntAct=EBI-747693, EBI-1052523;
PtmCleaved by caspases during apoptosis.
PtmPhosphorylation by IKBKB/IKKB at Ser-209 promotes its proteasome-mediated degradation. {ECO
SimilarityBelongs to the acetyltransferase family. ARD1 subfamily.
SimilarityContains 1 N-acetyltransferase domain.
Subcellular LocationCytoplasm. Nucleus. Note=According to PubMed:12464182 it is cytoplasmic. According to PubMed:15496142, it is nuclear and cytoplasmic. Also present in the free cytosolic and cytoskeleton-bound polysomes.
SubunitComponent of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA15 or NAA16. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, an down-regulates it when induced by hypoxia. Interacts with NAA50 and with the ribosome. Binds to MYLK. Associates with HYPK when in complex with NAA15. Interacts (via its C-terminal domain) with TSC2, leading to its acetylation. {ECO
Tissue SpecificityUbiquitous.