LMPD Database

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LMP001172

UniProt Annotations

Entry Information
Gene Nameplatelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Protein EntryPA1B2_HUMAN
UniProt IDP68402
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P68402-1; Sequence=Displayed; Name=2; IsoId=P68402-2; Sequence=VSP_042896; Name=3; IsoId=P68402-3; Sequence=VSP_043217; Name=4; IsoId=P68402-4; Sequence=VSP_044680; Note=Ref.2 (ABI58227/ABI58228) sequences are in conflict in position: 151:V->M. ;
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P68402-1; Sequence=Displayed; Name=2; IsoId=P68402-2; Sequence=VSP_042896; Name=3; IsoId=P68402-3; Sequence=VSP_043217; Name=4; IsoId=P68402-4; Sequence=VSP_044680; Note=Ref.2 (ABI58227/ABI58228) sequences are in conflict in position: 151:V->M. {ECO:0000305};
Catalytic Activity1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
FunctionInactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit.
SimilarityBelongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.
SimilarityBelongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitCytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.
Tissue SpecificityUbiquitous.
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:9144386}.