LMPD Database

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LMP001145

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol glycan anchor biosynthesis, class Q
Protein EntryPIGQ_HUMAN
UniProt IDQ9BRB3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BRB3-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9BRB3-2; Sequence=VSP_007281, VSP_007282; Name=3; IsoId=Q9BRB3-3; Sequence=VSP_007279, VSP_007280; Note=No experimental confirmation available.;
Catalytic ActivityUDP-N-acetyl-D-glucosamine + 1-phosphatidyl- 1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol.
FunctionPart of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
SimilarityBelongs to the PIGQ family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
SubunitAssociates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity.