LMPD Database

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LMP001143

UniProt Annotations

Entry Information
Gene Namearachidonate 5-lipoxygenase activating protein
Protein EntryAL5AP_MOUSE
UniProt IDP30355
SpeciesMouse
Comments
Comment typeDescription
DomainThe C-terminal part after residue 140 is mostly disordered. {ECO:0000250}.
FunctionRequired for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). unstructured (By similarity). {ECO:0000250}.
SimilarityBelongs to the MAPEG family. {ECO:0000305}.
Subcellular LocationNucleus membrane {ECO:0000269|PubMed:19075240}; Multi-pass membrane protein {ECO:0000269|PubMed:19075240}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitHomotrimer. Interacts with LTC4S and ALOX5. {ECO:0000269|PubMed:19075240}.