LMPD Database

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LMP001119

UniProt Annotations

Entry Information
Gene Namedegenerative spermatocyte homolog 1 (Drosophila)
Protein EntryDEGS1_MOUSE
UniProt IDO09005
SpeciesMouse
Comments
Comment typeDescription
FunctionHas sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). {ECO:0000269|PubMed:11937514}.
PtmMyristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels. {ECO:0000250}.
SimilarityBelongs to the fatty acid desaturase family. DEGS subfamily. {ECO:0000305}.
Subcellular LocationMitochondrion. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityDetected in testis. Detected in pachytene spermatocytes and round spermatids. {ECO:0000269|PubMed:9227906}.