LMPD Database

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LMP001106

UniProt Annotations

Entry Information
Gene Namesphingosine phosphate lyase 1
Protein EntrySGPL1_MOUSE
UniProt IDQ8R0X7
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivitySphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. {ECO:0000269|PubMed:9464245}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
FunctionCleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:9464245}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityHighest levels are found in liver, followed by kidney, lung, heart and brain. {ECO:0000269|PubMed:9464245}.